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October 2022 - Volume 1 - Issue 2

1. A case study of Kleine-Levin syndrome with decreased intracranial pressure in adolescent female

    Zhang Sumei, Hao Xinxin and Chen Xuan

      Department of Neurology, Taiyuan Central Hospital, Shanxi Province, 030009 PR China

We found a rare case of Kleine-Levin syndrome in an adolescent female with decreased intracranial pressure. The patient developed symptoms of decreased appetite, depression and anhedonia. The clinical symptoms were similar to an affective disorder of depression attack since the patient had periodic symptoms of excessive sleep and gluttony, accompanied by an involuntary special "Crouching phenomenon" involving hip and knee flexion while holding her legs tightly and lying on her knees. She was not considered narcoleptic after polysomnography and multiple sleep latency tests. Finally, a lumbar puncture revealed low intracranial pressure (65mmH2O). Hypothalamic orexin-A detected in the cerebrospinal fluid was at the lower normal limit....

2. Reduced modeling of pacemaker spiking in dorsal raphe nucleus and locus coeruleus neurons

      Ying Zhou, Henry C. Tuckwell and Nicholas J. Penington

        1Department of Mathematics, Lafayette College, 1 Pardee Drive, Easton, PA 18042, USA

        2School of Electrical and Electronic Engineering, University of Adelaide, Adelaide, South Australia 5005, Australia

        3Department of Physiology and Pharmacology,

        4Program in Neural and Behavioral Science and Robert F. Furchgott Center for Neural and Behavioral Science

        State University of New York, Downstate Medical Center, Box 29, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA

Many central neurons, particularly certain brainstem aminergic neurons, exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz. Many ion channel types contribute to such spiking, so accurate modeling of spike generation requires solving very large systems of differential equations, ordinary in the first instance. Since the analysis of spiking behavior when many synaptic inputs are active adds further to the number of components, it is useful to have simplified mathematical models of spiking in such neurons so that, for example, inputs and output spike features trains can be incorporated, including stochastic effects. In this article, we consider a simple two-component model whose solutions can mimic features of spiking in serotonergic neurons of the dorsal raphe nucleus and noradrenergic neurons of the locus coeruleus. The model is of the Fitzhugh-Nagumo type, and.....

3. An interesting case of combined central & peripheral demyelination with antibodies against paranodal

    protein neurofascin 186

       Zhang Sumei, Hao Xinxin and Chen Xuan

       Department of Neurology, Taiyuan Central Hospital, Shanxi Province, 030009 PR China

We report the diagnostic process of a rare patient with a combined central and peripheral demyelinating disease with antibodies against paranodal protein neurofascin 186 (anti–NF186)—the patient presented with weakness in both lower limbs. The clinical process and evidence are similar to subacute combined degeneration. However, thoracic spinal MRI shows T1 equal signal, and T2 high signal lesions in thoracic vertebrae 5-7 mainly involve white matter. The Aquaporin 4 antibody of the central nervous system indicates the disease is of an optic neuromyelitis pedigree. The antibodies against paranodal protein neurofascin 186 indicate demyelinating peripheral nerve pathogenesis. The final diagnosis was a combined central and peripheral demyelinating disease....

4. A Case of anti-Yo antibody positive subacute cerebellar degeneration presenting as acute cerebrovascular

    disease in an undiagnosed breast cancer patient

       Zhang Sumei, Hao Xinxin and Chen Xuan

       Department of Neurology, Taiyuan Central Hospital, Shanxi Province, 030009 PR China


A 41-year-old female patient presented initially with right limb ataxia, which resembled the clinical process of acute cerebrovascular disease. However, no obvious acute infarction was found on Cranial MR2. The patient's symptoms did not significantly improve after treatment with antiplatelet aggregation, stabilizing plate, clearing oxygen free radicals, and improving circulation. The patient was later diagnosed with subacute cerebellar degeneration by detecting Paratumor-related antibodies in cerebrospinal fluid and blood. Further investigation by PET-CT scan of the whole body revealed a breast tumor.

5. The activity of information in biomolecular systems: a fundamental explanation of holonomic brain theory

R. R. Poznanski1, E. Alemdar1,2, L.A, Cacha1, V.I. Sbitnev3,4  and E. J. Brändas5   

      1 Integrative Neuroscience Group, Melbourne, Australia

      2 Faculty of Medicine, Sakarya Üniversite, 54050 Serdivan/Sakarya, Turkey
      3 Petersburg B.P. Konstantinov Nuclear Physics Institute, Gatchina, Russian Federation
      4 Department of Electrical Engineering and Computer Science, University of California, Berkeley, USA
      5 Department of Chemistry, Uppsala University, 751 21 Uppsala, Sweden

We wish to suggest a mechanism for binding intrinsic information based on an inter-cerebral superfast, spontaneous information pathway involving protein-protein interactions. Protons are convenient quantum objects for transferring bit units in a complex water medium like the brain. The phonon-polariton interaction in such a medium adds informational complexity involving complex protein interactions that are essential for the superfluid-like highway to enable the consciousness process to penetrate brain regions due to different regulated gene sets as opposed to single region-specific genes. Protein pathways in the cerebral cortices are connected in a single network of thousands of proteins. To understand the role of inter-cerebral communication, we postulate protonic currents in interfacial water crystal lattices result from phonon-polariton vibrations, which can lead in the presence of more

6.  Effect of early morning awakening in major depressive disorder

       Xiaoxia Wu, Lei Ding, Neng Chen, Lijuan Gao*

          Nanhai Public Health Hospital of Foshan, Chancheng District, Foshan528253

            Guangdong Province, People’s Republic of China.

Patients with the major depressive disorder usually manifest with sleep disturbance. Early morning awakening is more closely related to major depressive disorder than other sleep disturbances. This study aimed to assess the effect of early morning awakening in treating patients with major depressive disorder. The eligible patients were divided into two groups according to whether they woke up at 2-4 a.m: early morning awakening and non-early morning awakening group. All patients were assessed using the Hamilton Depression Scale, Hamilton Anxiety Scale, and Repeatable Battery for the Assessment of Neuropsychological Status scores at baseline and the fourth week. Twenty-one men and 31 women (mean age 25.13 ±10.67 years) were enrolled. There was a significant main effect of early morning awakening in the Hamilton Depression Scale (P = 0.04) and Hamilton Anxiety Scale (P = 0.01) at the fourth week after treatment. But there was no significant difference in cognitive changes between the two groups. In conclusion, a major depressive disorder with early morning awakening may result in statistically and clinically significant delay in recovery.

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