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May 2022 - Volume 1 - Issue 1

1.   From integrative neuroscience to multiscale neuroscience

       Roman Poznanski 

       Integrative Neuroscience Group, AUS


2.   Sentiomics: the identification and analysis of dynamical patterns that characterize sentience

        A. Pereira  Junior,      and V. J. de Aguiar

      1 Universidade Estadual Paulista Júlio Mesquita Filho (UNESP/Botucatu) Botucatu, SP –Brasil.

      2 Doutorando no Centro de Filosofia das Ciências da Universidade de Lisboa (CFCUL), Lisboa – Portugal.

Sentience, defined as the capacity of feeling, for example, to experience basic sensations such as hunger, thirst and other types of qualitative mental states, is a psychobiological phenomenon that involves dynamic patterns of electrochemical (below 1Hz) and electromagnetic (above 1Hz) waves in living systems. The science we have called Sentiomics studies unconscious dynamic patterns in the brain that define the capacity for feeling. This paper discusses the explanation of creative processes based on unconscious patterns that combine and constructively interfere, generating a conscious output experienced in the living system's first-person perspective. We claim that the Sentiomics approach to wave interferences helps explain creative intuition, artistic creativity, the formation of dreams, and related phenomena. We raise a hypothesis – based on available evidence, to be experimentally tested – that the dominance of slower synchronized oscillatory frequencies (such as Delta, Theta and Alpha bands) in scalp electroencephalogram spectra makes more room for constructive electrochemical interferences supporting creativity. This research points to the dynamism of the unconscious mind since such interferences happen without the need for conscious control but are influenced by the degree of attention focusing. Once those dynamic processes are understood, they can be used to enrich mental life, boost creativity in general, and improve decision-making processes.

3.   What a feeling - the underpinnings of physical feelings as molecular level holonomic effects

      R.R. Poznanski,     L. A. Cacha,      J. Holmgren  and E. J. Brändas

       1Integrative Neuroscience Group

        2Department of Chemistry, Uppsala University, 751 21 Uppsala, Sweden

This paper proposes biophysical principles for why geometric holonomic effects through the geometric vector potential are sentient when harmonized by quantized magnetic vector potential in phase-space. These biophysical principles are based on molecular level electromagnetic resonances in partially holistic molecules where nonintegrated information acts as the consciousness process’s conduit—using the informational structure of physical feelings as a transition into subjectivity. The transformation of internal energies from potential to kinetic as ‘concealed’ motion may measure the causal capacity required to bridge causality for conscious experience. Conformational transitions produce bond-breaking, resulting in boundary conditions and limiting the molecular wavefunction to a partially holistic molecular environment with molecular holonomic effects. The van der Waals energy increases protein conformational activity (re-arrangement of bonds), causing energy transfer and information in protein-protein interactions across the cerebral cortex through the energy transduction process. Energy transitions predetermine molecular level electromagnetic resonances in aromatic residues of amino acids. The energy sharing between various nested molecular level electromagnetic resonances interacting with the intermolecular adhesion of London forces at the nexus between phospholipids and the lipophilic proteins has a key role in constraining the release of energy resulting in a vast array of information-based action through negentropic entanglement. Such information structure, passing from the objectivity of holonomic effects stemming from molecular level electromagnetic resonances, has an inherent ambiguity since meaning cannot be related to context, which constitutes preconscious experienceability. The transition from potentiality to actuality where Coulombic force is expressed as a smear of possible experiences where carriers of evanescent meanings instantly actualize through intermittent dispersion interactions as conscious experiences and return to potentiality in preconscious experienceabilities.

4.   The archetypal molecular patterns of conscious experience are quantum analogs

       J.A. Tuszynski,     R. R. Poznanski,     P. Singh, A. Pattanayak, L.A. Cacha,     M.A. Jalil,

      M. Thabet, T. Dutta, and A. Bandyopadhyay

        1Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R7, Canada

         2Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy

         3Integrative Neuroscience Group, Melbourne, Australia

         4International Center for Materials and Nanoarchitectronics, Research Center for Advanced Measurement & Characterization, NIMS, Tsukuba, Ibaraki, Japan   

         5Organizational Behavior and Human Resource Management, Indian Institute of Management, Ranchi, 834008, India

         6Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, 81310 Johor, Malaysia

         7Institute of Brain Chemistry & Human Nutrition, Department of Cancer & Surgery, Chelsea & Westminster Hospital Campus of Imperial College, SW London, UK                                                                                 

We define quantum analogs as vibrational excitations of quasi-particles coupled to electromagnetically-mediated resonance energy transfer in water (a crystal lattice). This paper addresses how neural magnetic resonance spectra of the brain’s magnetic field influence dipolar oscillation waves in crystal lattices of interfacial water molecules to produce correlates of phenomenal consciousness. We explore dipolar oscillation waves in hydrophobic protein cavities of aromatic amino acids as a conduit for coherent propagation of vibrational excitation and hydrogen bond distortion associated with phase coherence present in the magnetic field intensity oscillations at a frequency at which the energy switches from its trapped form as excited phonon states to free, cavity-mode magnetic field energy states. A quasi-polaritons that reflect “hydro-ionic waves” is a macroscopic quantum effect of crystal lattice vibrations, consisting of vibron polaritons coupled to ions across the neocortex, except the cerebellum, due to the absence of protein-protein interactions. They are quantum-like at the core and hence can exhibit quantum-like signaling properties when resonant energy is transferred as dipolar waves in hydrophobic protein cavities of aromatic amino acids. This is due to aromatic residue flexibility in molecular electromagnetic resonances. Finally, the archetypal molecular patterning of conscious experiences, which carries an inherent ambiguity necessary for non-contextually applying ‘meaning’ that encompasses cognitive signatures of conscious experience, satisfies the nature of quantum analogs and their transmutative properties.


5.  Neuronal circuits of stress and their dynamic interactions: a biopsychological framework

     L. A. Cacha      and R. R. Poznanski
   Integrative Neuroscience Group 

Stress responses are characterized by changes in neuroendocrine, autonomic, and behavioral systems to cope effectively with real and perceived threats that compromise one's wellbeing. It is the brain that determines which things are threatening, thus potentially stressful, and it is also responsible for triggering physiological and behavioral responses that can be either adaptive or harmful. The brain has to be understood as it reacts to stress-related disorders, and discern how adaptation mechanisms of the central nervous system are altered under acute stress conditions, as well as how stress-induced adaptation mechanisms are altered under chronic stress conditions. The current study investigated neuronal circuits of stress as well as their dynamic interactions with mediator molecules and metabolic-endocrine systems. During this interaction, the brain becomes more capable of resolving stress in a way that is either adaptive or maladaptive, leaving the most critical deficit in the emotion regulation associated with risk for pathological conditions. The essence of this associated risk involves the reciprocal influence between hypothalamic-pituitary-adrenal function, the relay nucleus within the amygdala reactivation, and the hippocampus as essential structures associated with the forebrain pathways mediating threat-induced hormones and the g -aminobutyric acid neurotransmitter system as central to the regulation of anxiety. Understanding how related emotional experience occurs on the neural level and its impact on cognition and behavior requires mapping the multi-step process of the hypothalamic-pituitary-adrenal axis and the hormones released by each of these structures through interactions between threat-sensitive brain circuitry and the responsivity of neuroendocrine fear-system. We integrate contributions from the medical, biological, cognitive neuroscience, and psychological sciences, we review the neurological bases of emotions and stress-related behavior.


 6.   Geomagnetism came first: Implications for animal translocation and the two-brains hypothesis

       G. Goodman, R.R. Poznanski,     L.A. Cacha     and D. Bercovich

       1Galil Genetic Analysis, Katzrin 12900 Israel

         2Integrative Neuroscience Group, Melbourne, Victoria Australia 3145

         3Department of Molecular Genetics, Faculty of Life Sciences, Tel-Hai Academic College Galilee, 12110 Israel


The relevance of the Two-Brains Hypothesis for induction between peripheral Schwann cells and their axon hosts and for intra- and trans-cranial bioengineering at the human-robotics interface is accompanied by particular attention to its significance for a biological wonder: the involvement of geomagnetism in avian directional behavior in migration, homing and navigation. Two sources of magnetism are considered here. The simpler is the polar (compass) direction, long reported as resulting in some birds in a manner unknown from the presence of magnetite (Fe3O4) in the avian ethmoid region. The second is certain chemical reactions that respond to applied magnetic fields. These usually involve radicals, molecules with unpaired electrons that spin in one of two possible states. A radical-pair mechanism, a light-dependent, chemical initiation of magnetic orientation, has been considered responsive to the axial inclination of the field in relation to Earth's field, but not to its polarity. The initiation is by optic but non-visually responsive cellular absorption of a photon of a specific wavelength. Radical pairs are short-lived and must be correctly aligned in the host receptors for directional sensitivity. The firmest evidence for the radical-pair theory of magneto-reception in birds remains the cryptochromes, the blue-light absorbing flavoproteins, but the receptor molecule has not been identified yet. Subjective thought and consciousness are also unexplained in birds,  as in humans and animals. However, the novel, structured dichotomy of the Two-Brains Hypothesis may provide a fresh, biophysical approach to the connection between geomagnetism, life and the evolution of vertebrate translocation without recourse to philosophy or a universe expanding beyond imagination.

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