The activity of information in biomolecular systems:
a fundamental explanation of holonomic brain theory

Small Running Title

R. R. Poznanski, E. Alemdar, L.A. Cacha, V.I. Sbitnev  and E. J. Brändas (2022). The activity of information in biomolecular systems: a fundamental explanation of holonomic brain theory. Journal of Multiscale Neuroscience 1(2), 109-133    https://doi.org/10.56280/1546792195
We wish to suggest a mechanism for binding intrinsic information based on an inter-cerebral superfast, spontaneous information pathway involving protein-protein interactions. Protons are convenient quantum objects for transferring bit units in a complex water medium like the brain. The phonon-polariton interaction in such a medium adds informational complexity involving complex protein interactions that are essential for the superfluid-like highway to enable the consciousness process to penetrate brain regions due to different regulated gene sets as opposed to single region-specific genes. Protein pathways in the cerebral cortices are connected in a single network of thousands of proteins. To understand the role of inter-cerebral communication, we postulate protonic currents in interfacial water crystal lattices result from phonon-polariton vibrations, which can lead in the presence of an electromagnetic field, to ultra-rapid communication where thermo-qubits, physical feelings, and protons that are convenient quantum objects for transferring bit units in a complex water medium. The relative equality between the frequencies of thermal oscillations due to the energy of the quasi-protonic movement about a closed loop and the frequencies of electromagnetic oscillations confirms the existence of quasi-polaritons. Phonon-polaritons are electromagnetic waves coupled to lattice vibrational modes. Still, when generated specifically by protons, they are referred to as phonon-coupled quasi-particles, i.e., providing a coupling with vibrational motions. We start from quasiparticles and move up the scale to biomolecular communication in subcellular, cellular and neuronal structures, leading to the negentropic entanglement of multiscale ‘bits’ of information. Espousing quantum potential chemistry, the interdependence of intrinsic information on the negative gain in the steady-state represents the mesoscopic aggregate of the microscopic random quantum-thermal fluctuations expressed through a negentropically derived, temperature-dependent, dissipative quantum potential energy. The latter depends on the time derivative of the spread function and temperature, which fundamentally explains the holonomic brain theory.

Keywords: Quantum potential chemistry; quantum-thermal fluctuations; thermo-qubits; intrinsic information; Grotthuss mechanism; negentropic gain; quasi-polaritons; protons; dissipative quantum potential energy; resonance; holonomic brain theory.

 

Conflict of Interest

    The authors declare no conflict of interest

CFP.png
APC.png