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A case study of Kleine-Levin syndrome with decreased intracranial

pressure in adolescent female


Zhang Sumei,  Hao  Xinxin   and   Chen Xuan  (2022).  A   case   study   of   Kleine-Levin   syndrome   with   decreased  intracranial  pressure  in  adolescent  female. Journal  of  Multiscale  Neuroscience 1(2), 77-82


We found a rare case of Kleine-Levin syndrome in an adolescent female with decreased intracranial pressure. The patient developed symptoms of decreased appetite, depression and anhedonia. The clinical symptoms were similar to an affective disorder of depression attack since the patient had periodic symptoms of excessive sleep and gluttony, accompanied by an involuntary special "Crouching phenomenon" involving hip and knee flexion while holding her legs tightly and lying on her knees. She was not considered narcoleptic after polysomnography and multiple sleep latency tests. Finally, a lumbar puncture revealed low intracranial pressure (65mmH2O). Hypothalamic orexin-A detected in the cerebrospinal fluid was at the lower normal limit. After symptomatic treatment involving fluid infusion and increasing intracranial perfusion pressure, the patient's periodic symptoms and social functioning improved with reduced instances of the special "Crouching phenomenon."

Keywords: Depressive episode, Narcolepsy, Kleine-Levin, syndrome, Hypothalamus, Orexin A, Low intracranial pressure

Conflict of Interest

    The authors declare no conflict of interest

Copyright: © 2022 The Author(s). Published by Neural Press.

This is an open access article distributed under the terms and conditions of the CC BY 4.0 license.

Disclaimer: The statements, opinions, and data in the Journal of Multiscale Neuroscience are solely those of the individual authors and contributors, not those of the Neural Press™ or the editors(s).

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