An interesting case of combined central and peripheral demyelination with

antibodies against paranodal protein neurofascin 186

​

Zhang Sumei, Hao Xinxin and Chen Xuan (2022). A case study of combined central  and  peripheral  demyelination with antibodies against paranodal protein neurofascin 186.  Journal of Multiscale Neuroscience 1(2), 96-101    https://doi.org/10.56280/1534198194   h

 

CLINICAL CASE REPORT

We report the diagnostic process of a rare patient with a combined central and peripheral demyelinating disease with antibodies against paranodal protein neurofascin 186 (anti– NF186)—the patient presented with weakness in both lower limbs. The clinical process and evidence are similar to subacute combined degeneration. However, thoracic spinal MRI shows T1 equal signal, and T2 high signal lesions in thoracic vertebrae 5-7 mainly involve white matter. The Aquaporin 4 antibody of the central nervous system indicates the disease is of an optic neuromyelitis pedigree. The antibodies against paranodal protein neurofascin 186 indicate demyelinating peripheral nerve pathogenesis. The final diagnosis was a combined central and peripheral demyelinating disease based on the results of various examinations. The patient's condition improved after methylprednisolone therapy and intravenous immunoglobulin.

​

Keywords: Subacute combined degeneration of spinal cord; neuromyelitis optic spectrum disease; combined central and
peripheral demyelination.

​

Conflict of Interest

The authors declare no conflict of interest

​

Copyright: © 2022 The Author(s). Published by Neural Press.

This is an open access article distributed under the terms and conditions of the CC BY 4.0 license.

​

Disclaimer: The statements, opinions, and data in the Journal of Multiscale Neuroscience are solely those of the individual authors and contributors, not those of the Neural Press™ or the editors(s).

​