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Article Timeline
Published online:
28 Oct 2022
Accepted:
2 Oct 2022
Received:
19 Aug 2022
Open Access
Original Research
The activity of information in biomolecular systems: a fundamental explanation of holonomic brain theory
R. R. Poznanski, E. Alemdar, L.A. Cacha, V.I. Sbitnev and E. J. Brändas
Author Affiliations
R. R. Poznanski: Integrative Neuroscience Group, Melbourne, Australia.
E. Alemdar:
Integrative Neuroscience Group, Melbourne, Australia
Faculty of Medicine, Sakarya Üniversite, 54050 Serdivan/Sakarya, Turkey.
L.A. Cacha: Integrative Neuroscience Group, Melbourne, Australia.
V.I. Sbitnev:
Petersburg B.P. Konstantinov Nuclear Physics Institute, Gatchina, Russian Federation.
Department of Electrical Engineering and Computer Science, University of California, Berkeley, USA.
E. J. Brändas: Department of Chemistry, Uppsala University, 751 21 Uppsala, Sweden.
Abstract
We wish to suggest a mechanism for binding intrinsic information based on an inter-cerebral superfast, spontaneous information pathway involving protein-protein interactions. Protons are convenient quantum objects for transferring bit units in a complex water medium like the brain. The phonon-polariton interaction in such a medium adds informational complexity involving complex protein interactions that are essential for the superfluid-like highway to enable the consciousness process to penetrate brain regions due to different regulated gene sets as opposed to single region-specific genes. Protein pathways in the cerebral cortices are connected in a single network of thousands of proteins. To understand the role of inter-cerebral communication, we postulate protonic currents in interfacial water crystal lattices result from phonon-polariton vibrations, which can lead in the presence of an electromagnetic field, to ultra-rapid communication where thermo-qubits, physical feelings, and protons that are convenient quantum objects for transferring bit units in a complex water medium. The relative equality between the frequencies of thermal oscillations due to the energy of the quasi-protonic movement about a closed loop and the frequencies of electromagnetic oscillations confirms the existence of quasi-polaritons. Phonon-polaritons are electromagnetic waves coupled to lattice vibrational modes. Still, when generated specifically by protons, they are referred to as phonon-coupled quasi-particles, i.e., providing a coupling with vibrational motions. We start from quasiparticles and move up the scale to biomolecular communication in subcellular, cellular and neuronal structures, leading to the negentropic entanglement of multiscale ‘bits’ of information. Espousing quantum potential chemistry, the interdependence of intrinsic information on the negative gain in the steady-state represents the mesoscopic aggregate of the microscopic random quantum-thermal fluctuations expressed through a negentropically derived, temperature-dependent, dissipative quantum potential energy. The latter depends on the time derivative of the spread function and temperature, which fundamentally explains the holonomic brain theory.
Keywords
Quantum potential chemistry; quantum-thermal fluctuations; thermo-qubits; intrinsic information; Grotthuss mechanism; negentropic gain; quasi-polaritons; protons; dissipative quantum potential energy; resonance; holonomic brain theory.
How to cite this article
R. R. Poznanski, E. Alemdar, L.A. Cacha, V.I. Sbitnev and E. J. Brändas (2022). The activity of information in biomolecular systems: a fundamental explanation of holonomic brain theory. Journal of Multiscale Neuroscience 1(2), 109-133.
Conflict of Interest
The authors declare no conflict of interest.
Copyright
© 2022 The Author(s). Published by Neural Press. This is an open access article distributed under the terms and conditions of the CC BY 4.0 license.
Disclaimer
The statements, opinions, and data in the Journal of Multiscale Neuroscience are solely those of the individual authors and contributors, not those of the Neural Press or the editors(s).
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