top of page
Hypo Zhang.png
Zhang Image.png
Roman figure.png
Gao fihure.png
Volume 1 Issue 2 (October 2022) 

Clinical Case Report

A case study of Kleine-Levin syndrome with decreased intracranial pressure in adolescent female

Zhang Sumei, Hao Xinxin and Chen Xuan


We found a rare case of Kleine-Levin syndrome in an adolescent female with decreased intracranial pressure. The patient developed symptoms of decreased appetite, depression and anhedonia. The clinical symptoms were similar to an affective disorder of depression attack since the patient had periodic symptoms of excessive sleep and gluttony, accompanied by an involuntary special "Crouching phenomenon" involving hip and knee flexion while holding her legs tightly and lying on her knees. She was not considered narcoleptic after polysomnography and multiple sleep latency tests. Finally, a lumbar puncture revealed low intracranial pressure (65mmH2O). Hypothalamic orexin-A detected in the cerebrospinal fluid was at the lower normal limit ....

Original Research

Reduced modeling of pacemaker spiking in dorsal raphe nucleus and locus coeruleus neurons

Ying Zhou, Henry C. Tuckwell and Nicholas J. Penington


Many central neurons, particularly certain brainstem aminergic neurons, exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz. Many ion channel types contribute to such spiking, so accurate modeling of spike generation requires solving very large systems of differential equations, ordinary in the first instance. Since the analysis of spiking behavior when many synaptic inputs are active adds further to the number of components, it is useful to have simplified mathematical models of spiking in such neurons so that, for example, inputs and output spike features trains can be incorporated, including stochastic effects. In this article, we consider a simple two-component model whose solutions can mimic features of spiking in serotonergic neurons ..... 

Clinical Case Report
An interesting case of combined central & peripheral demyelination with antibodies against paranodal protein neurofascin 186

Zhang Sumei, Hao Xinxin and Chen Xuan

We report the diagnostic process of a rare patient with a combined central and peripheral demyelinating disease with antibodies against paranodal protein neurofascin 186 (anti–NF186)—the patient presented with weakness in both lower limbs. The clinical process and evidence are similar to subacute combined degeneration. However, thoracic spinal MRI shows T1 equal signal, and T2 high signal lesions in thoracic vertebrae 5-7 mainly involve white matter. The Aquaporin 4 antibody of the central nervous system indicates the disease is of an optic neuromyelitis pedigree. The antibodies against paranodal protein neurofascin 186 indicate demyelinating peripheral nerve pathogenesis. The final diagnosis was a combined central and peripheral demyelinating disease....

Clinical Case Report
A Case of anti-Yo antibody positive subacute cerebellar degeneration presenting as acute cerebrovascular disease in an undiagnosed breast cancer patient

Zhang Sumei, Hao Xinxin and Chen Xuan

Department of Neurology, Taiyuan Central Hospital, Shanxi Province, 030009 PR China


A 41-year-old female patient presented initially with right limb ataxia, which resembled the clinical process of acute cerebrovascular disease. However, no obvious acute infarction was found on Cranial MR2. The patient's symptoms did not significantly improve after treatment with antiplatelet aggregation, stabilizing plate, clearing oxygen free radicals, and improving circulation. The patient was later diagnosed with subacute cerebellar degeneration by detecting Paratumor-related antibodies in cerebrospinal fluid and blood. Further investigation by PET-CT scan of the whole body revealed a breast tumor. 

Original Research

The activity of information in biomolecular systems: a fundamental explanation of holonomic brain theory

R. R. Poznanski, E. Alemdar, L.A, Cacha, V.I. Sbitnev and E. J. Brändas  


We wish to suggest a mechanism for binding intrinsic information based on an inter-cerebral superfast, spontaneous information pathway involving protein-protein interactions. Protons are convenient quantum objects for transferring bit units in a complex water medium like the brain. The phonon-polariton interaction in such a medium adds informational complexity involving complex protein interactions that are essential for the superfluid-like highway to enable the consciousness process to penetrate brain regions due to different regulated gene sets as opposed to single region-specific genes. Protein pathways in the cerebral cortices are connected in a single network of thousands of proteins. To understand the role of inter-cerebral communication, we postulate protonic currents in interfacial water crystal lattices result from phonon-polariton vibrations, which can lead in the presence .....

Brief Report

Effect of early morning awakening in major depressive disorder

Xiaoxia Wu, Lei Ding, Neng Chen, Lijuan Gao


Patients with the major depressive disorder usually manifest with sleep disturbance. Early morning awakening is more closely related to major depressive disorder than other sleep disturbances. This study aimed to assess the effect of early morning awakening in treating patients with major depressive disorder. The eligible patients were divided into two groups according to whether they woke up at 2-4 a.m: early morning awakening and non-early morning awakening group. All patients were assessed using the Hamilton Depression Scale, Hamilton Anxiety Scale, and Repeatable Battery for the Assessment of Neuropsychological Status scores at baseline and the fourth week. Twenty-one men and 31 women (mean age 25.13 ±10.67 years) were enrolled. There was a significant main effect of early morning awakening in the Hamilton Depression Scale (P = 0.04) and Hamilton Anxiety Scale (P = 0.01) at the fourth week after treatment. But there was no significant difference in cognitive changes between the two groups. In conclusion, a major depressive disorder with early morning awakening may result in statistically and clinically significant delay in recovery.

bottom of page